HEMATOLOGICAL AND HISTOPATHOLOGICAL ADVERSE EFFECTS OF KMNO4 ON MICE


Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects

BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia is a phenomenon resulting in dose esca

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Insights into the Roles of B Cells in Patients with Sepsis

Sepsis is a life-threatening yet common disease, still posing high mortality worldwide.Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function citroen c4 grand picasso boot liner of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis.Dysfunction of B cell

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Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons

Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects.We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this citroen c4 grand picasso boot liner cytokine-like effect depends on TIMP-1 endocytosis mediated by th

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